Numol*- MR

Numol*- MR

The Maestro Among Muscle Relaxants

D E S C R I P T I O N / M O D E O F A C T I O N 

Aceclofenac is a novel NSAID known to exhibit multifactor mechanism of action
Directly blocks PGE 2 secretion at the site of inflammation by inhibiting IL-Beta & TNF in the inflammatory cells

Blocks degeneration and stimulates synthesis of extracellular matrix of cartilages by inhibiting the action of different cytokines.

Inhibit IL-6 production by human chondrocytes.

Suppression of GAG [Glucosaminoglycan] and collagen synthesis and stimulates growth factor mediated synthesis of GAG and collagen.

Inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.

Well absorbed from GIT, peak plasma concentration are reached 1-3 hr, 99% plasma protein bound, Plasma elimination half-life is approximately- 4hrs.

Thiocolchicoside: Thiocolchicoside is a natural derivative of colchicine & a semi-synthetic derivative of colchicoside. Thiocolchicoside acting as a GABA-A receptor antagonist, its myorelaxant effects could be exerted at the supra-spinal level, via complex regulatory mechanisms, although a glycinergic mechanism of action cannot be excluded.

C O M P O S I T I O N 

C O M P O S I T I O N
Numol MR 4 Tablets Each Tablet contains Aceclofenac 100mg + Thiocolchicoside 4mg
Numol MR 8 Tablets Each Tablet contains Aceclofenac 100mg + Thiocolchicoside 8mg



I N D I C AT I O N S 

I N D I C AT I O N S
Degenerative vertebral disorders
Torticollis (Wry neck)
Dorsal pain and low back pain
Neurological disorders



D O S A G E 

Numol MR 4 – twice a day for 5 to 7 days
Numol MR 8 – once a day for 5 to 7 days

 

S I D E E F F E C T S 

Aceclofenac is generally well tolerated and has got a superior side effects profile as compared to other NSAIDS. However, it must be used with caution in patients with peptic ulcers, hyper acidity, severe hepatic, cardiac or renal insufficiency. Aceclofenac cannot be used with triametrene and methotrexate and children less than 18 months of age. It is to be used with care in pregnant / lactating women. Leukocytoclastic vasculitis & haemoptysis
Side effect of skeletal muscle relaxants may include: sedation, drowsiness, blurred or double vision, constipation or diarrhea, dizziness and drowsiness, nervousness and confusion, dry mouth, dyspepsia (chronic or recurrent pain in the upper abdomen, upper abdominal fullness, and feeling full earlier than expected when eating), fatigue, headache, heartburn, hiccups and nausea, insomnia, stomach cramps, trembling, vomiting, and weakness; and possible dependence following long-term use, Photosensitivity reactions.

P R E S E N T A T I O N & PACK 

NUMOL – MR 4mg & 8mg Tablets – Strips of 10×10’s in blister packs