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Lotace*

The Comprehensive Management of Hypertension

D E S C R I P T I O N / M O D E O F A C T I O N 

Losartan potassium, the first of a new class of antihypertensives, is  an angiotensin II receptor (type AT1) antagonist. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1[p-(o-1H-tetrazol-5-dylphenyl)benzyl]imidazole-5-methanol monopotassium salt. Angiotensin II [formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II), is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). There is also an AT2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Both losartan and its principal active metabolite do not exhibit any partial agonist activity at the AT1 receptor and have much greater affinity (about 1000-fold) for the AT1 receptor than for the AT2 receptor. The active metabolite is 10 to 40 times more potent by weight than losartan.

C O M P O S I T I O N 

Lotace 25 Tabs Each Tablet contains Losartan Potassium 25 mg
Lotace 50 Tabs Each Tablet contains Losartan Potassium 50 mg



I N D I C AT I O N S 

Mild to moderate essential hypertension
Cardiac failure
Diabetic nephropathy
Left Verntricular dysfuction
Myocardial infarction



D O S A G E 

Lotace 25 / 50 : One tablet once or twice daily

S I D E E F F E C T S 

Fetopathic potential – Not to be administered during pregnancy.
Angioedema is reported in few cases, Headache, dizziness, weakness, upper GI side effects are mild.

P R E S E N TAT I O N & PACK 

Lotace 25 Tablets Blister pack of 10 x 10’s Tablets
Lotace 50 Tablets Blister pack of 10 x 10’s Tablets